Metaphenylenediamines

ABSTRACT

Couplers having the general formula (I): ##STR1## or the acid salts thereof in which formula R is either 
     (a) hydrogen or 
     (b) a C 1  -C 3  alkyl or 
     (c) a C 1  -C 3  hydroxyalkyl, and 
     Z is either 
     (a) hydroxyalkyl, or 
     (b) alkoxyalkyl in which the alkoxy group contains 1 to 2 carbon atoms, or 
     (c) mesylaminoalkyl, or 
     (d) acetylaminoalkyl, or 
     (e) ureidoalkyl, or 
     (f) carbethoxyaminoalkyl 
     the alkyl groups in the radicals constituting Z comprising from 2 to 3 carbon atoms and 
     Z is not hydroxyethyl when R is hydrogen. 
     These couplers form dyeing compositions when mixed with an oxidation base consisting of a paraphenylenediamine having the general formula: ##STR2##

RELATED APPLICATIONS

This application is a continuation-in-part of application Ser. No.826,069 filed Aug. 19, 1977, now abandoned which in turn is acontinuation-in-part of Ser. No. 722,819, filed Sept. 13, 1976 (now U.S.Pat. No. 4,125,367).

BACKGROUND

In the field of dyeing keratinic fibers, hair and furs, themetaphenylenediamines play an important role which has been known for along time. They form part of the class of compounds currently called"couplers". The couplers, in association with the paraphenylenediaminesor the paraaminophenols--compounds called oxidation bases--produce in analkaline oxidizing medium colored indamines, indoanilines orindophenols.

The association of the metaphenylenediamines with theparaphenylenediamines in an oxidizing alkaline atmosphere, and inparticular in the presence of hydrogen peroxide, produce indaminescapable of imparting to keratinic fibers very strong blue colors.

Moreover, the metaphenylenediamines associated with the paraaminophenolsproduce in an oxidizing alkaline atmosphere, indoanilines, which impartto keratinic fibers more or less purple-red colorations.

The metaphenylenediamines thus play, when considered as couplers, adouble role in capillary dyeing: Contribution of blue and red, that isto say contribution of two fundamental colors which are indispensable toobtain not only blacks and greys, but also burnt or copper chestnuts.

Despite its important role this category of couplers is presentlyrestricted in practice to a very limited number of compounds. This verylimited number is explained by the fact that one may only keep forcapillary dyeing on the one hand those beneficial compounds of a goodinnocuousness, and on the other hand the compounds permitting to obtaindyes of good qualities, that is to say, which do not change with time,in particular neither under light, nor inclement weather. By way ofexample, metatoluylene diamine is not satisfactory for reasons ofnon-innocuousness, while 1-methyl-2-amino-N-methyl-4-amino benzene,2-amino-N-methyl-4-amino anisole, 2-amino-4-amino-N-methyl anisole,2-amino-N-β-hydroxyethyl 4-amino anisole, 1-methyl2-amino-N-β-hydroxyethyl-4-amino benzene lead to shades which areunstable with time, both in darkness and in the light. This instabilityis due principally to the ready cyclization into azinic molecules of theindoamines or indoanilines formed in situ during the oxidation dyeing,the azines formed then undergoing rapid photochemical degradation in thelight.

THE PRESENT INVENTION

The present invention relates to new chemical compounds which arecapable of functioning as couplers usable in hair dyeing compositions.The compounds according to the present invention are particularly usablein capillary dyeing because they combine a very good innocuousness withthe dyeing qualities of a good coupler.

More specifically, the present invention involves chemical compounds ofthe general formula: ##STR3## or the acid salts thereof in which formulaR is either

(a) hydrogen or

(b) a C₁ -C₃ alkyl or

(c) a C₁ -C₃ hydroxyalkyl, and

Z is either

(a) hydroxylakyl, or

(b) alkoxyalkyl in which the alkoxy group contains 1 to 2 carbon atoms,or

(c) mesylaminoalkyl, or

(d) acetylaminoalkyl, or

(e) ureidoakyl, or

(f) carbethoxyaminoalkyl

the alkyl groups in the radicals constituting Z comprising from 2 to 3carbon atoms, and

Z is not hydroxyethyl when R is hydrogen.

The compounds of the present invention can be used to form a dyeingcomposition for keratinic fibers and in particular for hair, saidcomposition containing, in aqueous solution, at least one oxidation basethat contains as a coupler, at least one compound of formula (I).

With the greater part of the paraphenylenediamines, in an alkalineoxidizing medium, the compounds of formula (I) impart to the hair strongblue colorations, more or less rich in green or in purple, resistant tothe light, to bad weather, and to shampooing.

In a general way, in the dyeing composition containing the compounds ofthe present invention one may use as oxidation bases theparaphenylenediamines of the general formula (II): ##STR4## or thecorresponding acid salts; in which R₁, R₂ and R₃ are identical ordifferent and represent hydrogen, alkyl having 1 to 2 carbon atoms oralkoxy having 1 to 2 carbon atoms, R₄ and R₅ are identical or differentand represent hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, in which thealkoxy group comprises 1 to 2 carbon atoms, carbamylalkyl,mesylaminoalkyl, acetylaminoalkyl, ureidoalkyl, carbethoxyaminoalkyl,the alkyl groups in R₄ and R₅ having 1 to 3 carbon atoms, with thereservation that R₁ or R₃ represent hydrogen when R₄ and R₅ do notrepresent hydrogen.

It should be noted however, that the paraphenylenediamines having achlorine or fluorine atom on the ring yield with the compounds (I)violet colorations, which rapidly lose their chromaticity in the light.This is the case, for example, with 3-chloro-4-amino-N-β-hydroxyethylaniline or 3-fluoro-4-amino-N-β-hydroxyethyl aniline.

To illustrate the invention we hereafter describe by way of purelyillustrative and non-limiting examples, the preparation and use of thefollowing specific compounds under formula (I):

1. Dihydrochloride of (2-amino-4-N-methylamino) phenoxyethanol.

2. Dihydrochloride of (2,4-diamino) phenylmethoxyethylether.

3. Dihydrochloride of (2,4-diamino) phenylmesylaminoethylether.

These three compounds give, in particular, blue colorations of very goodstability with the following oxidation bases: paraphenylenediamine,paratoluylenediamine, 2-methyl 5-methoxy paraphenylenediamine,2,6-dimethyl-3-methoxy paraphenylenediamine, 2,6-dimethylparaphenylenediamine, 4-amino-N-methoxyethyl aniline,4-amino-N,N-ethyl-carbamylmethyl aniline and4-amino-N,N-di-β-hydroxyethyl aniline.

A certain number of compounds of formula (I) offer, from the dyeingpoint of view, the supplemental advantage of being able to also givestable reds when they are associated with paraaminophenol or2-methyl-4-amino phenol. The dyeing compositions containing thesecompounds may then contain at the same time paraphenylene diamines andparaaminophenols.

For the other compounds of formula (I) which do not offer thissupplementary advantage, one may in order to provide the red and violetnecessary to the formulation of a capillary dyeing composition, add tothe dyeing compositions containing them in addition to theparaphenylenediamines of formula (II) on the one hand leuco derivativesof indoanilines or indophenols such as: the4,4'-dihydroxy-2-amino-5-methyl diphenylamine,4,4'-dihydroxy-2-amino-N-β-hydroxyethyl-5-methyl-2'-chlorodiphenylamine, 2,4'-diamino-4-hydroxy-5-methyl diphenylamine and on theother hand direct dyes such as, for example,3-nitro-4-amino-N-β-hydroxyethyl phenol, 2-β-hydroxyethyl-amino-5-nitroanisole.

Dyeing compositions containing the compounds of the present inventionmay also contain in addition to the coupler or couplers of the formula(I) and the oxidation base or bases associated therewith, the followingproducts taken singly or in combination:

1. Other known couplers, for example, resorcin, metaaminophenol,2-methyl-5-amino phenol, 2-methyl-5-amino-N-β-hydroxyethyl phenol,6-hydroxy benzomorpholine, 2,6-dimethyl-5-acethyl-amino phenol,2-methyl-5-carbethoxyamino phenol, 2-methoxy-5-carbethoxyamino phenol,2-methyl-5-ureido phenol;

2. Polyaminophenols, monoaminodiphenols, diaminodiphenols, polyphenolssuch as trihydroxybenzene;

3. Leucoderivatives of indoaniline or indophenols;

4. Direct dyes and preferably nitrated dyes of the benzene series suchas 1-amino-N,N-di-β-hydroxyethyl-3-nitro-4-amino N'-methyl benzene,1-amino-N,N-methyl-β-hydroxyethyl-3-nitro-4-amino-N'-β-hydroxyethylbenzene, 1-amino-N,N-methyl-β-hydroxyethyl-3-nitro-4-amino-N'-methylbenzene, 3-nitro-4-amino-N-β-hydroxyethyl anisole,3-nitro-4-amino-N-β-hydroxyethyl phenol, (3-nitro-4-amino)phenoxyethanol, (3-nitro-4-amino-N-methyl) phenoxyethanol,2-amino-β-hydroxyethyl-5-nitro anisole;

5. Various usual additives such as penetrating agents, foaming agents,thickening agents, anti-oxidizing agents, alkalizing agents, perfumes,sequestrating agents, and film forming products.

The pH of the dyeing compositions described above usually have a basicpH, for example between 8 and 11.5. We prefer a pH between about 9 and10. Among the alkalizing agents which may be used, there can bementioned ammonia, the alkyl amines the alkanolamines, the hydroxides ofsodium or potassium, and the carbonates of sodium, potassium orammonium.

We may also add to the dye composition hydrosoluble anionic, cationic,non-ionic, or amphoteric surface-active agents. Among the surface activeagents particularly useful there may be mentioned the alkyl benzenesulfonates, the alkylnaphthalene sulfonates, the sulfates, ethersulfates and sulfonates of fatty alcohols, quaternary ammonium salts,such as triethyl cetylammonium bromide, cetyl pyridinium bromide, thediethanolamides of fatty acids, the acids and the polyoxyethylenatedalcohols and the polyoxyethylenated alkylphenols. Preferably, thesurface active agents are present in the dyeing composition in aproportion between about 0.5 and 30% by weight, and preferably betweenabout 4 and 25% by weight.

One may also add to the dye composition organic solvents to solubilizethe compounds which are not sufficiently soluble in water. Among thesolvents which may advantageously be used one may mention by way ofexample ethanol, isopropanol, glycerin, glycols like butyl glycol,ethylene glycol, propylene glycol, monoethylether, and monomethyletherof diethylene glycol and analogous products. The solvents mayadvantageously be present in the composition in an amount ranging from 1to 40% by weight and preferably between 5 and 30% by weight.

The thickening products which may be added to the dye composition may besodium alginate, gum arabic, cellulose derivatives such asmethylecullulose, hydroxyethylcellulose, hydroxypropyl methylcellulose,the sodium salt of carboxymethylcellulose, or polymers of acrylic acid.One may also use mineral thickening agents such as bentonite. Preferablythe thickening agents are present in an amount between 0.5 and 5% byweight based on the total weight of the composition and preferablybetween 0.5 and 3% by weight.

The antioxidizing agents which one may add to the dye composition may besodium sulfite, thioglycolic acid, the acid sulfite of sodium, ascorbicacid, or hydroquinone. The anti-oxidizing agents may be present in thecomposition in an amount between 0.05 and 1% by weight based on thetotal weight of the composition.

The dyeing composition may contain oxidizing agents such as hydrogenperoxide, urea peroxide, or the persalts such as ammonium persulfate.

In a general way, the compounds of formula (I) are present in the dyeingcomposition in an amount between 0.001 and 2.5% by weight based on thetotal weight of the composition.

The dyeing composition may be in the form of a liquid solution, a paste,a cream or gel, or any other appropriate form for bringing about adyeing of keratinic fibers.

The compounds of formulas (I) may be easily prepared from compoundsdescribed in French patent application Nos. 74 36651 filed Nov. 5, 1974and 76 12985 filed Apr. 30, 1976 and which are incorporated herein byreference.

Beginning with these benzene compounds nitrated in the meta positionwith respect to the amine group, it suffices to bring about a reductionto transform the nitro group into an amine group and possibly theneffectuate the acid hydrolysis in the case in which the startingproducts comprises an acetylated amine function.

In order that the objectives of the present invention may be betterunderstood, there will hereafter be described, purely by way ofillustrative and non-limiting examples, the preparation of severalcompounds of formula (I) and the use of these compounds in dyeingcompositions.

EXAMPLE 1 Preparation of dihydrochloride of (2-amino 4-N-methylamino)phenoxyethanol ##STR5##

The starting compound is described in Example 5 of French PatentApplication No. 74-36651 filed Nov. 5, 1974.

In 60 ml of hydrochloric acid (density=1.19 at 75° C.) one addssimultaneously, little by little, under agitation 0.05 mols (10.6 g) of(2-nitro 4-amino-N-methyl) phenoxyethanol and 14.3 g of tin powder.After completion of the additions, one continues the agitation for 15minutes at 90° C. The reaction mixture is drained hot. Filtrate isevaporated until dry under a vacuum. The residue is dissolved in 300 mlof water and the tin is precipitated in the form of the sulfide bybubbling with hydrogen sulfite. It is filtered. The filtrate isconcentrated to 15 ml under a vacuum. The concentrated solution iscooled to -10° C. The dihydrochloride of the expected productcrystallizes. It is drained, washed with very little ice water and thenvacuum dried. It melts with decomposition 26 225° C. The analysis of theproduct gives the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.9 H.sub.16 N.sub.2 O.sub.2 Cl.sub.2                                                    Found                                                 ______________________________________                                        C %        42.35            42.08                                             H %        6.27             6.45                                              N %        10.98            10.77                                             Cl %       27.84            27.73                                             ______________________________________                                    

EXAMPLE 2 Preparation of dihydrochloride of (2,4-diamino)phenyl-β-methoxyethylether ##STR6## First Step Preparation of(2-acetylamino 4-amino) phenyl β-methoxyethylether

To 100 ml of water to which 4 ml of acetic acid has been added and whichhas already been heated to 90° C., one adds 13 g of powdered iron and,little by little, under agitation, 0.078 mol (20 g) of2-acetylamino-4-nitro) phenyl-β-methoxy-ethylether (product described inthe first step of Example 8 of French Pat. No. 76-12985 filed Apr. 30,1976, in the name of the applicant). The addition being terminated, onemaintains the reaction mixture in the boiling water bath for 30 minutes.It is filtered hot. After the addition of sodium chloride to thefiltrate, the expected product precipitates by salting out. It isdrained, washed with very little ice water. It melts at 130° C.

Second Step Preparation of dihydrochloride of (2,4-diamino)phenyl-β-methoxyethylether

0.067 mol (15 g) of 2-acetylamino 4-amino) phenyl-β-methoxyethylether isintroduced into 30 ml of 36% hydrochloric acid. One heats 30 minutes inthe boiling water bath. After cooling the dihydrochloride of theexpected product crystallizes. It is drained, recrystalized in alcohol,and vacuum dried. The product melts with decomposition at 215° C.

The analyis gives the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.9 H.sub.16 N.sub.2 O.sub.2 Cl.sub.2                                                    Found                                                 ______________________________________                                        C %        42.35            42.47                                             H %        6.27             6.34                                              N %        10.98            10.85                                             Cl %       27.84            27.83                                             ______________________________________                                    

EXAMPLE 3 Preparation of dihydrochloride of (2,4-diamino)phenyl-mesylaminoethylether ##STR7## First Step Preparation of(2,4-diacetylamino)-phenyl-mesylaminoethylether

Into 20 ml of water to which 2 ml of acetic acid has been added andwhich has been brought to 90° C., one adds 3.5 g of powdered iron and,little by little, under agitation, 0.02 mol (5.5 g) of (4-nitro-6-amino)phenyl mesylaminoethylether (product described in Example 12 of FrenchPat. No. 76-12985. The reflux is maintained under agitation for 30minutes. It is drained while boiling and the precipitate washed inboiling water. 6 ml of acetic anhydride is added to the filtrate and thereaction medium heated for several minutes in a boiling water bath.After cooling the expected product crystallizes. It is drained, washedwith water, vacuum dried. It melts at 191° C.

Second Step Preparation of dihydrochloride of (2,4-diamino)phenyl-mesylaminoethylether

One heats for 45 minutes in a boiling water bath 0.017 mol (5.6 g) of(2,4-diacetylamino) phenyl-mesylaminoethylether in 14 ml of hydrochloricacid at 36%. After cooling, the dihydrochloride of the expected productprecipitates in crystallized form. The product is drained,recrystallized in alcohol and vacuum dried at 60° C.

Analysis gives the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.9 H.sub.17 N.sub.3 O.sub.3 S Cl.sub.2                                                  Found                                                 ______________________________________                                        C %        33.96            33.93                                             H %        5.38             5.45                                              N %        13.20            13.12                                             Cl %       22.28            22.10                                             S %        10.08            10.15                                             ______________________________________                                    

EXAMPLE 4

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2       0.127 g                                           4-amino-N-ethyl-N-carbamylmethyl aniline                                                                  0.193 g                                           Butylglycol                 20 g                                              Lauric alcohol having 10.5 mols of ethylene oxide                                                         8 g                                               Ammonia at 22° B.    4.5 g                                             Water, q.s.                 100 g                                             ______________________________________                                    

The pH is 10.3.

At the moment of use one adds 35 g of hydrogen peroxide at 20 volumes.This mixture applied to 95% naturally white hair for 20 minutes atambient temperature imparts thereto, after rinsing and shampooing, a skyblue coloration.

EXAMPLE 5

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 3      0.016 g                                            Sulfate of 3-methyl-4-methylethylamino aniline                                                           0.028 g                                            Carboxymethylcellulose     5 g                                                Water, q.s.                100 g                                              Ammonia at 22° B.   6 g                                                ______________________________________                                    

The pH is equal to 11.

At the moment of use 15 g of hydrogen peroxide at 20 volumes is added.

This mixture applied for 25 minutes at 30° C. to bleached hair impartsthereto, after rinsing and shampooing, a sky blue coloration.

EXAMPLE 6

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2      0.255 g                                            Dihydrochloride of 4-amino-N-methyl aniline                                                              0.195 g                                            Oleic alcohol oxyethylenated with 2 mols of                                   ethylene oxide             3 g                                                Oleic alcohol oxyethylenated with 4 mols of                                   ethylene oxice             4.4 g                                              Ammonia at 22° B.   6 g                                                Water, q.s.                100 g                                              ______________________________________                                    

The pH is equal to 10.

At the moment of use 25 g of hydrogen peroxide at 20 volumes is added.

This mixture is applied for 10 minutes at 30° C. to 90% naturally whitehair imparts thereto, after rinsing and shampooing, a royal bluecoloration.

EXAMPLE 7

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 3        0.954 g                                          Dihydrochloride of 2,6-dimethyl-3-methoxy                                     paraphenylenediamine         1.43 g                                           Alkyl ammonium sulfate in C.sub.12, C.sub.14 (70% of C.sub.12 and             30% of C.sub.14)             15 g                                             Lauric alcohols having 10.5 mols of ethylene oxide                                                         5 g                                              Ammonia at 22° B.     10 g                                             Water, q.s.                  100 g                                            ______________________________________                                    

The final pH is equal to 10.2.

At the moment of use, 75 g of hydrogen peroxide at 20 volumes is added.This mixture applied for 20 minutes at 25° C. to 95% naturally whitehair imparts thereto, after rinsing and shampooing, a clear pure bluecoloration.

EXAMPLE 8

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2      0.12 g                                             Trihydroxybenzene          0.82 g                                             N-ethyl-4-amino-N-carbamylmethyl aniline                                                                 2.6 g                                              3-nitro-4-N-amino-β-hydroxyethyl phenol                                                             0.29 g                                             Alcohol at 96%             20 g                                               Triethanolamine            6 g                                                Water, q.s.                100 g                                              ______________________________________                                    

The pH is equal to 9.

At the moment of use 60 g of hydrogen peroxide at 20 volumes is added.

This mixture applied to bleached hair for 20 minutes at 20° C. impartsthereto, after rinsing and shampooing, a deep brown coloration havinglight violet glints.

EXAMPLE 9

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2       0.2 g                                             Dihydrochloride of 2-methyl-5-methoxy                                         paraphenylenediamine        0.2 g                                             4-amino-N,N-β-hydroxyethyl aniline sulfate                                                           0.2 g                                             Metaaminophenol             0.3 g                                             6-hydroxy benzomorpholine   0.1 g                                             3-nitro-4-amino-N-β-hydroxyethyl anisole                                                             0.2 g                                             4-mino-N-methyl phenol sulfate                                                                            0.4 g                                             Monomethyl ester of diethyleneglycol                                                                      9 g                                               Ammonia at 22° B.    10 g                                              Water, q.s.                 100 g                                             ______________________________________                                    

The pH is equal to 10.7.

At the moment of use 100 g of hydrogen peroxide at 20 volumes is added.

This mixture applied for 30 minutes at 20° C. to bleached hair impartsthereto, after rinsing and shampooing, a very deep reddish chestnutcoloration.

EXAMPLE 10

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 3       0.105 g                                           Resorcin                    15 g                                              Dihydrochloride of 2,6-dimethyl-5-methoxy                                     paraphenylenediamine        0.3 g                                             1-phenyl-3-methyl pyrazolone                                                                              0.1 g                                             3-nitro-4-amino-N-β-hydroxyethyl phenol                                                              0.2 g                                             Hydrochloride of (2-amino-4-nitro) phenoxyethanol                                                         0.25 g                                            4,4'-dihydroxy-2-amino-5-methyl diphenylamine                                                             0.4 g                                             Butylglycol                 15 g                                              Nonylphenol having 4 mols of ethylene oxide                                                               8 g                                               Nonylphenol having 9 mols of ethylene oxide                                                               9 g                                               Ammonia at 22° B.    5 g                                               Water, q.s.                 100 g                                             ______________________________________                                    

The pH is equal to 9.8.

At the moment of use, 80 g of hydrogen peroxide at 20 volumes is added.

This mixture applied for 25 minutes at 20° C. to bleached hair impartsthereto, after rinsing and shampooing, a clear golden chestnutcoloration.

EXAMPLE 11

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2       0.13 g                                            3-fluoro-4-amino-N-hydroxyethyl aniline sulfate                                                           0.22 g                                            Trihydrochloride of 4-amino-N-diethyl-2,6-diamino                             phenol                      0.12 g                                            N[(4-hydroxy) phenyl]-2-methyl-5-amino                                        benzoquinone imine          0.70 g                                            Butylglycol                 5 g                                               Lauric alcohol oxyethylenated with 10.5 mols of                               ethylene oxide              5 g                                               Triethanolamine             1.1 g                                             Water, q.s.                 100 g                                             ______________________________________                                    

At the moment of use, 10 g of urea peroxide is added in 100 g of water.

This mixture applied for 25 minutes at 20° C. to bleached hair impartsthereto, after rinsing and shampooing, a burnt beige grey coloration.

EXAMPLE 12

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 3     0.075   g                                           Dihydrochloride of (2,4-diamino)phenoxyethanol                                                          0.025   g                                           Resorcin                  0.11    g                                           m-amino phenol            0.1     g                                           4-amino-N-phenol sulfate  0.2     g                                           4-amino-N-β-methoxyethyl aniline sulfate                                                           0.3     g                                           3-nitro-4-amino phenoxyethanol                                                                          0.3     g                                           2,4'-diamino-4-hydroxy-5-methyl diphenylamine                                                           0.25    g                                           2-amino-N-β-hydroxyethyl-5-nitro-anisole                                                           0.125   g                                           Hydroquinone              0.0325  g                                            ##STR8##                 3.33    g                                           (R being an oleyl radical)                                                     ##STR9##                 4.95    g                                           (R being an oleyl radical)                                                    Propyleneglycol           6.6     g                                           Ammonia at 22° B.  10      g                                           Water, q.s.               100     g                                           ______________________________________                                    

The pH is equal to 10.3.

At the moment of use 75 g of hydrogen peroxide at 20 volumes is added.

This mixture applied for 20 minutes at ambient temperature to 95%naturally white hair imparts thereto, after rinsing and shampooing, abronze coloration.

EXAMPLE 13

The following dyeing composition is prepared:

    ______________________________________                                        Dye of example 1            0.14 g                                            Dihydrochloride of 2,6-dimethyl-3-methoxy                                     paraphenylenediamine        0.20 g                                            Trihydrochloride of 4-amino-N-diethyl-2,6-diamino                             phenol                      0.1 g                                             N[(4-hydroxy) phenyl]2-methyl-5-amino                                         benzoquinone imine          0.5 g                                             Butylglycol                 5 g                                               Lauric alcohol oxyethylenated with 10.5 mols                                  of ethylene oxide           5 g                                               Triethanolamine             1.1 g                                             Water, q.s.                 100 g                                             ______________________________________                                    

The pH is equal to 8.

10 g of urea peroxide in solution in 100 g of water is added at themoment of use.

This solution applied for 20 minutes at ambient temperature to bleachedhair imparts thereto, after rinsing and shampooing, a deep greycoloration.

EXAMPLE 14

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 1      0.20 g                                             Paraaminophenol            0.60 g                                             4-amino-N-β-methoxyethyl aniline sulfate                                                            0.325 g                                            Metaaminophenol            0.44 g                                             (3-nitro-4-amino) phenoxyethanol                                                                         0.25 g                                             Butylglycol                20 g                                               Diethanolamides of fatty acids of copra                                                                  7.4 g                                              Ammonia at 22° B.   6 g                                                Water, q.s.                100 g                                              ______________________________________                                    

The pH is equal to 10.5.

At the moment of use 100 g of hydrogen peroxide at 20 volumes is added.This dyeing composition applied for 20 minutes at 25° C. to 95%naturally white hair imparts thereto, after rinsing and shampooing, agolden chestnut coloration.

EXAMPLE 15

The following dyeing composition is prepared:

    ______________________________________                                        Compound of example 2      0.0012 g                                           4-amino-N-β-methoxyethyl aniline sulfate                                                            0.00125 g                                          Butylglycol                7.5 g                                              Product sold under the commercial name of                                     "Carbopol 934"             3.37 g                                             Polymer of acrylic acid (M.W. = 2-3 millions)                                 manufactured by the Goodrich Chemical Co.                                     Ammonia to 22° B.   7.5 g                                              Water, q.s.                100 g                                              ______________________________________                                    

The pH is equal to 8.

At the moment of use, 15 g of hydrogen peroxide at 20 volumes is added.This composition applied for 30 minutes at 25° C. to bleached hairimparts thereto, after rinsing and shampooing, a clear blue coloration.

EXAMPLE 16 Preparation of dichlorohydrate of (2,4-diamino)phenoxypropanol. ##STR10## First Step Preparation of (2,4-dinitro)phenoxypropanol

To a mixture of 0.2 mol (40.5 g) of 2,4-dinitro chlorobenzene and of1.12 mol (81 cm³) of 1,3-propanediol, heated to 90° C. is added in 30minutes 1.1 mol (81 cm³) of 1,3-propanediol in 20 cm³ of 10 N sodiumhydroxide.

After 45 minutes of heating at 90° C., the reactive medium is pouredover 250 g of an ice/water mixture. The expected product crystallizes.

After recrystallization in the isopropyl alcohol/ether mixture, oneobtains a product melting at 58° C.

Analysis yields the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.9 H.sub.10 N.sub.2 O.sub.6                                                             Found                                                 ______________________________________                                        C %        44.63            44.52                                             H %        4.13             4.42                                              N %        11.57            11.34                                             ______________________________________                                    

Second Step Preparation of dichlorhydrate of (2,4-diamino)phenoxypropanol

0.039 mol (9.5 g) of (2,4-dinitro) phenoxypropanol in 30 cm³ of absolutealcohol are reduced on Pd/C at 10% in a bomb under 25 kg of pressure ofhydrogen at 70° C. for 1 hour.

After cooling, it is filtered on 0.117 mol (17 cm³) of hydrochloricalcohol (i.e. ethanol into which is bubbled gaseous hydrochloric aciduntil saturation, e.g. 3-4 hours).

The expected dichlorohydrate crystallizes. The product is dried, washedwith alcohol, then with ether and dried in a vacuum. It melts withdecomposition at 158° C. Analysis yields the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.9 H.sub.16 N.sub.2 O.sub.2 Cl.sub.2                                                    Found                                                 ______________________________________                                        C %        42.35            42.20                                             H %        6.27             6.42                                              N %        10.98            11.13                                             Cl %       27.84            (27.92)                                                                       (27.84)                                           ______________________________________                                    

EXAMPLE 17

The following dyeing composition is prepared:

    ______________________________________                                        Dichlorhydrate of (2,4-diamino) phenoxypropanol                                                           0.637 g                                           Paraphenylenediamine        0.270 g                                           Sodium laurylsulfate with 2 mols of ethylene oxide                                                        20 g                                              Tetraacetic ethylenediamine acid                                                                          0.2 g                                             Sodium bisulfite in solution d = 1.32                                                                     1 g                                               20% ammonia                 10 g                                              Water q.s.p.                100 g                                             ______________________________________                                    

The pH equals 10.5.

At the time of use, 100 g of hydrogen peroxide at 20 volumes is added.This mixture applied for 20 minutes at 25° C. to naturally white hair at90% gives it, after rinsing and shampooing, a marine blue color withpurple highlights.

EXAMPLE 18

The following dyeing composition is prepared:

    ______________________________________                                        Dichlorhydrate of (2,4-diamino) phenoxypropanol                                                           0.637 g                                           Paraminophenol              0.272 g                                           Sodium laurylsulfate with 2 mols of ethylene oxide                                                        20 g                                              Tetraacetic ethylenediamine acid                                                                          0.2 g                                             Sodium bisulfite in solution d = 1.32                                                                     1 g                                               20% ammonia                 10 g                                              Water q.s.p.                100 g                                             ______________________________________                                    

The pH equals 10.5.

At the time of use, 100 g or H₂ O₂ at 20 volumes is added. This mixtureapplied for 20 minutes at 25° C. to naturally white hair at 90% givesit, after rinsing and shampooing, a dark red, slightly purple, color.

EXAMPLE 19 Preparation of dichlorhydrate of (2,4-diamino)phenyl,β-acetylamino-ethylether ##STR11## First Step Preparation of(2-acetamino 4-nitro) phenyl,β-acetylaminoethylether

0.021 mol (2cm³) of acetic anhydride is added to the suspension of0.0167 mol (4 g) of (2-acetamino 4-nitro) phenyl, β-amino-ethylether in20 cm³ of dioxane. After 15 minutes of agitation at 50° C., it ischilled in an ice bath.

The product formed is dried, washed with petroleum ether and dried in avacuum at 55° C.

It melts at 202°-203° C.

Second Step Preparation of (2-amino 4-nitro)phenyl,β-acetaminoethylether

0.00817 mol (2.3 g) of (2-acetamino 4-nitro) phenyl,β-acetaminoethylether are heated for one hour in HCl (1 N).

After cooling, it is neutralized with NH₄ OH. The expected productcrystallizes. After recrystallization in alcohol, it melts at 125° C.

Elementary analysis yields the following results:

    ______________________________________                                                 Calculated for                                                                C.sub.10 H.sub.13 N.sub.3 O.sub.4                                                            Found                                                 ______________________________________                                        C %        50.20            50.39                                             H %        5.48             5.41                                              N %        17.57            17.59                                             ______________________________________                                    

Third Step Preparation of dichlorohydrate of (2,4-diamino)phenyl,β-acetylaminoethylether

0.0079 mol (1.9 g) of (2-amino 4-nitro)-phenyl, β-acetylaminoethyletherin 30 cm³ of absolute alcohol is reduced on Pd/C at 10%, under ahydrogen pressure of 30 kg at 60° C. for half an hour.

After cooling, it is percolated through 3 cm³ of hydrochloric alcohol(ethanol in which is bubbled gaseous hydrochloric acid until saturation,e.g. 3 or 4 hours). By dilution with ether, the expected productcrystallizes. After centrifugal drying and then drying in a vacuum, itmelts with decomposition starting at 270° C.

Theoretical mass calculated for C₁₀ H₁₅ N₃ O₂, 2HCl:282.2

Molecular mass found by potentiometric titration in H₂ O by NaOH N/10.

PM₁ :281. 1st inflection

PM₂ :287.5 2nd inflection

EXAMPLE 20

The following dyeing composition is prepared:

    ______________________________________                                        Dichlorhydrate of (2,4-diamino) phenyl, β-                               acetaminoethylether        0.706 g                                            Dichlorhydrate of paratoluylene diamine                                                                  0.487 g                                            2-Butoxy ethanol           5 g                                                Lauric alcohol with 10.5% ethylene oxide                                                                 5 g                                                Ammonia (22° Baume) 10 g                                               Water q.s.p.               100 g                                              ______________________________________                                    

The pH equals 10.3.

At the time of use, 100 g of hydrogen peroxide at 20 volumes is added.This mixture applied for 20 minutes at 20° C. to naturally white hair to90% gives it, after rinsing and shampooing, a nice clear blue color.

EXAMPLE 21 Preparation of dichlorohydrate of [4-N(β-hydroxyethyl)-amino2-amino] phenoxyethanol ##STR12## First Step Preparation of (4-acetamino2-nitro)phenoxyethanol

0.1 mol (19.6 g) of 4-acetamino 2-nitro phenol in 100 cm³ ofdimethylformamide is heated to 80° C. Then 0.24 mol (16.8 g) ofpotassium hydroxide at 80% and 0.24 mol (30 g) of glycol bromhydrine areadded by fractions during 41/2 hours of heating in a boiling water bath.

The reactive medium is then poured on 300 g. of an ice water mixture.The expected product crystallizes. After filtration washing and drying,it melts at 169° C.

Second Step Preparation of (4-amino 2-nitro)phenoxyethanol

0.106 mol of (4-acetamino 2-nitro) phenoxyethanol (25.5 g) is heated ina boiling water bath in 35 cm³ of HCl for 45 minutes.

By cooling, the chlorhydrate of the expected product precipitates. Afterfiltration, it is added to 100 g of iced water and neutralized with NH₄OH. The expected product is filtrated washed and dried in a vacuum; itmelts at 86° C.

Theoretical mass: 198

Molecular mass found by potentiometric titration in CH₃ COOH by HClO₄N/10: 204

Third Step Preparation of [(3-nitro 4-β-hydroxyethoxy)phenyl] carbamateof β-chlorethyl

0.0605 mol (12 g) of (4-amino 2-nitro) phenoxyethanol is dissolved in 40cm³ of dioxane. 0.033 mol (3.3 g) of calcium carbonate is added and thetemperature is raised to about 90° C. During agitation, 0.066 mol (9.4g) of chloroformiate of β-ethyl chloride is added. After this addition,the agitation is continued for 11/2 hours at 90° C. The reactive mediumis filtered while hot and 60 g of an ice water mixture is added.

The resulting product which has precipitated is filtrated. After washingand drying, it melts at 84° C.

Fourth Step Preparation of [4-N-(β-hydroxyethyl)-amino 2-nitro]phenoxyethanol

0.0446 mol (13.6 g) of [(3-nitro 4-β-hydroxyethoxy)phenyl] carbamate ofβ-ethylchloride is added to 51 cm³ of NaOH 5 N. It is agitated for halfan hour at 80° C. The reactive medium is cooled to 0° C. and neutralizedwith HCl. The resulting product is extracted withmethyl-isobutyl-ketone. The solvent is driven out under reducedpressure. The resulting product is in the form of a red oil.

Fifth Step Preparation of dichlorhydrate of [4-N-(β hydroxyethyl)-amino2-amino] phenoxyethanol.

0.0392 mol (9.5 g) of [4-N-(β hydroxyethyl)-amino 2-nitro]phenoxyethanol in 30 cm³ of absolute alcohol is reduced on Pd/C at 10%in a bomb under 50 kg of pressure of H₂ for 45 minutes at 60° C.

After cooling it is percolated thru 0.096 mol (12 cm³) of hydrochloricalcohol.

The expected dichlorohydrate crystallizes. It is filtrated, washed,dried with ethyl ether, and dried in a vacuum at 55° C. It melts withdecomposition at 223° C.

Theoretical mass calculated for C₁₀ H₁₆ N₂ O₃ 2HCl: 285

Molecular mass obtained by potentiometric titration in water by NaOHN/10: 290.

EXAMPLE 22

The following dyeing mixture is prepared:

    ______________________________________                                        Dichlorhydrate of [4-N-(β-hydroxyethyl) -amino 2-amino]                  phenoxyethanol               0.427 g                                                                       0.276 g                                          Paraphenylenediamine         0.270 g                                          Butoxy-2 ethanol             5 g                                              Lauric alcohol at 10.5 mol of ethylene oxide                                                               5 g                                              Ammonia (22° Baume)   10 g                                             Water q.s.p.                 100 g                                            ______________________________________                                    

The pH equals 10.3.

At the time of use, 100 g of H₂ O₂ at 20 volumes are added. This mixtureapplied for 25 minutes at 20° C. to naturally white hair at 90% givesit, after rinsing and shampooing, a deep violet blue color.

EXAMPLE 23

The following dyeing mixture is prepared:

    ______________________________________                                        Dichlorhydrate of [4-N-(β-hydroxyethyl) -amino 2-amino]                  phenoxyethanol               0.712 g                                          Paraphenylene diamine        0.270 g                                          Sodium laurylsulfate with 2 mol of ethylene                                   oxide                        20 g                                             Tetraacetic ethylenediamine acid                                                                           0.2 g                                            Sodium bisulfite in solution d = 1.32                                                                      1 g                                              Ammonia (22° Baume)   10 g                                             Water q.s.p.                 100 g                                            ______________________________________                                    

The pH equals 10.4.

At the time of use, 100 g of hydrogen peroxide at 20 volumes are added.This mixture applied for 20 minutes at 20° C. to naturally white hair at90% gives it, after rinsing and shampooing, a purplish blue-grey color.

EXAMPLE 24 Preparation of dichlorhydrate of (2,4-diamino)phenyl,β-ureidoethyl ether ##STR13## First Step Preparation of(2-acetamino 4-nitro)phenyl,β-ureidoethyl ether

To 0.0209 mol (5 g) of (2-acetamino 4-nitro) phenyl,β-amino ethyl etherin 15 cm³ of water and 2.5 cm³ of HCl is added all at once 0.23 mol(1.86 g) of potassium cyanate in solution in 6 cm³ of water.

It is agitated for 3 hours at 40° C., then kept at room temperature forthree days.

After filtration, washing first with 1 N HCl then with water, theexpected product results, melting at 230°-231° C.

Second Step Preparation of (2-amino 4-nitro)phenyl,β-ureidoethyl ether

0.007 mol (2 g) of (2-acetamino 4-nitro) phenyl, β-ureidoethyl ether isheated in 15 cm³ of 1 N HCl for 1 hour and 15 min. After cooling, thereactive mixture is diluted with 15 g of ice and neutralized with NH₄OH.

After filtration, washing with H₂ O and drying in a vacuum on P₂ O₅, theexpected product melts at 208° C.

Third Step Preparation of dichlorhydrate of (2,4-diamino)phenylβ-ureidoethyl ether

0.00565 mol (1.35 g) of (2-amino 4-nitro) phenyl, β-ureido-ethyl etherin 5 cm³ of absolute alcohol is reduced on Pd/C at 10% in a bomb under50 kg of hydrogen pressure for one hour at 60°-70° C. After cooling, itis filtered on 0.016 mol (2 cm³) of hydrochloric alcohol. Afterenergetic agitation, the expected dichlorhydrate precipitates. Afterfiltration washing with ether and drying, it melts with decomposition at175° C.

Theoretical mass calculated for C₉ H₁₄ N₄ O₂, 2HCl: 283

Molecular mass found by potentiometric titration in H₂ O by NaOH N/10:298

EXAMPLE 25

The following dyeing composition is prepared:

    ______________________________________                                        Dichlorhydrate of (2,4-diamino)phenyl, β-ureidoethyl                     ether                        0.340 g                                          Dichlorhydrate of paratoluylenediamine                                                                     0.487 g                                          Sodium laurylsulfate wtih 2 mol of ethylene oxide                                                          20 g                                             Tetraacetic ethylenediamine  0.2 g                                            Sodium bisulfite in solution of d = 1.32                                                                   1 g                                              Ammonia at 20%               10 g                                             Water q.s.p.                 100 g                                            ______________________________________                                    

The pH equals 10.4.

At the time of use, 100 g of H₂ O₂ at 20 volumes is added. The mixtureapplied for 25 minutes at 20° C. to white hair at 90% gives it afterrinsing and shampooing a steel blue-grey color. What is claimed is:

1. Compounds having the formula: ##STR14## or the acid salts thereof inwhich formula R is hydrogen and Z is mesylaminoethyl.